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Big Pharma Stocks: Year-to-Date Performance and Market Outlook

Johnson & Johnson (JNJ) leads with an 11.30% YTD total return, supported by its diversified portfolio and successful drug launches.

What You Need to Know


• Johnson & Johnson (JNJ) leads with an 11.30% YTD total return, reflecting strong investor confidence.
• Merck & Co. (MRK) faces a 13.95% YTD decline, struggling with competitive pressures.
• Pfizer Inc. (PFE) experiences a modest 0.80% YTD drop, adjusting post-pandemic strategies.
• Novartis AG (NVS) gains 9.87% YTD, driven by strong sales of blockbuster drugs.
• GSK (GSK) rises 8.04% YTD, backed by a £2 billion share buyback plan.
• Novo Nordisk (NVO), despite high demand for its obesity drugs, sees a 3.05% YTD decline.

Market Overview

As of February 20, 2025, the pharmaceutical sector has delivered mixed performance. Johnson & Johnson (JNJ) leads with an 11.30% YTD total return, supported by its diversified portfolio and successful drug launches. Meanwhile, Novartis (NVS) and GSK (GSK) report 9.87% and 8.04% YTD gains, reflecting investor optimism.

On the other hand, Merck (MRK) struggles with a 13.95% YTD decline, while Pfizer (PFE) remains nearly flat, dropping 0.80% YTD amid post-pandemic adjustments. Novo Nordisk (NVO), despite leading the obesity drug market, has seen a 3.05% YTD drop, possibly due to supply constraints and tariff risks.

Company Performance Breakdown

Johnson & Johnson (JNJ) – $159.68 (▲11.30% YTD)

JNJ has benefited from a strong drug pipeline and diversified revenue streams across pharmaceuticals, medical devices, and consumer health.

Merck & Co. (MRK) – $87.68 (▼13.95% YTD)

MRK faces headwinds from slower growth in Keytruda sales and increasing competition, leading to a double-digit YTD drop.

Pfizer Inc. (PFE) – $25.90 (▼0.80% YTD)

The post-COVID revenue decline continues to weigh on Pfizer, though advances in vaccine technology provide some upside potential.

Novartis AG (NVS) – $107.31 (▲9.87% YTD)

Novartis has seen strong demand for Entresto (heart failure) and Cosentyx (autoimmune) drugs, contributing to its stock’s upward trajectory.

GSK plc (GSK) – $36.96 (▲8.04% YTD)

GSK has announced a £2 billion share buyback, reflecting confidence in its vaccine and specialty medicine pipeline.

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Novo Nordisk (NVO) – $83.74 (▼3.05% YTD)

Despite a 26% increase in 2024 sales, Novo Nordisk has faced supply shortages for its obesity drug Wegovy, and potential tariff concerns could be affecting its stock.

The Oracle Says

“The Oracle says investors should focus on pharmaceutical companies with strong pipelines and new product launches, as they are best positioned to navigate market volatility.”

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